The despair that victims experience can all too quickly consume them and destroy their lives.
But a year after the launch of its "foreign ministry", though, the despair is palpable.
Businessman Muhammad Khan, 40, who recently returned to Mingora, voiced the despair of returning residents.
That itself, for many Japanese looking back to the despair of last spring, is a remarkable achievement.
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Nor should Westerners overdo the despair, for the emergence of new great powers will benefit them, too.
Importantly, the partnership should now fasten on messaging that directly addresses the despair among consumers that Cunningham depicts.
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More than any cinema music, it enacts the despair and stubborn persistence of our attempts to re-create the past.
Few films capture with such life-affirming wonder the despair, hatred, and incomprehension that drives the sexes together and apart.
As John Cleese's character in Clockwise put it: "I can take the despair, it's the hope I can't stand".
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It hurts to look into the despair on the children's faces, to see a toddler barefoot on the gravel.
The National Farmers' Union says its members need emergency help from the government to relieve the despair that many are feeling.
The biggest challenge is to ward off the despair and the indifference.
They have discounted the despair and disappointment that comes with thwarted ambition.
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But this precipitated the despair that led him to end his life.
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Is it necessary, for example, to refer to the work on battle fatigued second-world-war soldiers, in order to explain the despair of the castaways?
Through this letter, we learn of the despair of Jim and his children at Kate's death, and of the subsequent meaninglessness of their lives.
"Faced with such horror, we are compelled to turn the despair in our hearts into unshakeable resolve that this will not happen to our children, " she said.
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Nevertheless, he said he visited his son four days ago and the man appeared fine and gave no hint of the despair that could drive him to take his own life.
From the kitchen-sink ordinariness of the working-class Belfast upbringing towards stardom on the pitch at United, renown as a Sixties socialite and eventually the infamy of alcoholism with the despair and trouble it brought.
McCamant bought Genentech during the depths of despair in the summer of 2002.
The first thing you notice is how, just over a year ago, the headlines were about the fury and despair at the closure of services.
As barbaric and unacceptable as this type of punishment appears, I could not avoid appreciating the sincerity and despair of the person speaking to me.
But interestingly, for all the apparent despair about prospects manifested in PwC's annual global survey of chief executives, I find the bosses I encounter surprisingly optimistic.
"I, poor, miserable Robinson Crusoe, being shipwrecked, during a dreadful storm, in the offing, came on shore on this dismal, unfortunate island, which I called the Island of Despair, all the rest of the ship's company being drowned, and myself almost dead, " Crusoe writes in his first entry.
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After a brief stint as a psychiatric hospital for children and teenagers in the 1980s, the building fell into despair in the late 1990s and sat vacant for years.
In many conflict-affected countries, over 60% of the population is aged under 25, but education systems are not providing youth with the skills they need to escape poverty, unemployment and the economic despair that often contributes to violent conflict.
The tendency towards hyperbole may stem from the sense of despair among some scientists at the way climate change has disappeared from much of public discourse since the double whammy of Copenhagen and Climategate.
The hopelessness and despair that is engulfing fans of the Mets today will only be temporary.
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