Phase I Trials of Molecularly Targeted Agents: Should We Pay More Attention to Late Toxicities?

分子靶向药物I期临床试验：我们更应多注重晚期毒性？

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On average, fewer than 5% of participants in phase I trials respond successfully to the treatment.

平均来说，在第一期试验中只有不到5%的参与者对于治疗反应良好。

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The real state of the world is that five anti-TB molecules are in phase I trials and two are in phase II.

事实情况是，有五种抗肺结核分子正处于试验阶段I，有两种处于试验阶段II。

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The company hopes to begin its Phase I trials by the end of 2008.

FORBES: Nanotech Puts Cancer In The Cross Hairs

New Phase I trials should begin at the end of the year for vaccines being developed by drug giant GlaxoSmithKline (nyse: GSK - news - people) and another set of trials is being run by the National Institutes of Health but are not included in the chart below because sufficient data was not available.

FORBES: Magazine Article

Almost all of these vaccines, however, are in Phase I clinical trials--early-stage tryouts meant to judge safety, not effectiveness.

FORBES: Magazine Article