In this paper, the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated.

这篇论文主要研究的是第i阶段临床试验中最大耐受剂量的估计问题。

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Studies on phase I clinical trials of artesunate tablet were carried out with double blind method in 22 male healthy volunteers.

以双盲法对22名健康男性志愿者进行青蒿琥酯片口服的耐受性和不良反应研究。

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Methods Retrospective review of transaminase data collected on placebo during 2 phase I clinical trials in 16 healthy volunteers, who were either hospitalized for 2 days or 13 days.

方法在2个新药I期临床试验中，对多次服用安慰剂、住院时间为2天或13天的16名健康志愿者多次进行转氨酶检查。

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Almost all of these vaccines, however, are in Phase I clinical trials--early-stage tryouts meant to judge safety, not effectiveness.

FORBES: Magazine Article

The excitement over Canadian-based YM and its presentation of data from phase I and II clinical trials at ASCO centers not only on its positive data on myelofibrosis but on indications its JAK inhibitors may also have applications in solid tumors, as well as inflammatory diseases, says Chrystyna Bedrij, biotech analyst at Griffin Securities.

FORBES: YM Biosicences: Its Data at ASCO On Drug for Bone Marrow Disorders Catapults Its Stock

While other pharmaceutical companies have paid large amounts of cash for biotech drugs that had nearly completed human testing, Roche (otc: RHHBY - news - people ) has been sticking mostly to those that are in the earliest (phase I) or middle (phase II) stages of clinical trials.

FORBES: Roche Goes For Early Stage Biotechs