Phase I Trials of Molecularly Targeted Agents: Should We Pay More Attention to Late Toxicities?
分子靶向药物I期临床试验：我们更应多注重晚期毒性？
On average, fewer than 5% of participants in phase I trials respond successfully to the treatment.
平均来说，在第一期试验中只有不到5%的参与者对于治疗反应良好。
The real state of the world is that five anti-TB molecules are in phase I trials and two are in phase II.
事实情况是，有五种抗肺结核分子正处于试验阶段I，有两种处于试验阶段II。
The same is true of medical researchers recruiting volunteers for clinical trials, especially those known as phase I trials, in which a new drug is tested on people for the first time.
对于医学研究人员也是同样情形。他们招募志愿者参加临床试验，主要是将新药物首次使用于人体的第一阶段试验。
Phase I trials: These first studies in people evaluate how a new drug should be given (by mouth, injected into the blood, or injected into the muscle), how often, and what dose is safe.
一期试验：这些首次在人体上进行的试验评估一个新药应该如何给药(口服，注射入血还是肌肉注射)，给药间隔和给药的安全剂量。
This definition includes Phase I to Phase IV trials.
其定义包括第1阶段到第4阶段的试验。
I saw excellence in research and institutional capacities, where 11 centres across the region are now conducting phase 3 trials of a potentially revolutionary malaria vaccine.
我看到，非洲区域的研究机构已具备良好的研究能力，分布全区各地的11所研究中心正对可能带来巨大变化的疟疾疫苗进行第三期试验。
Five African countries are currently conducting phase I and phase II clinical trials of candidate HIV vaccines: Botswana, Kenya, Rwanda, South Africa, Uganda, soon to be joined by Tanzania.
五个非洲国家目前正在开展候选艾滋病毒疫苗的一期和二期临床试验：博茨瓦纳、肯尼亚、卢旺达、南非、乌干达，坦桑尼亚很快也将介入。
The experiments produced evidence that patients will absorb more of the unnamed drug, tested in Phase I in clinical trials, when taken with "flat" or degassed Sprite.
这些实验得出证据证明，当服用“不发泡”或脱气雪碧时，患者将吸收更多的I期临床实验中测验的未命名药物。
In this paper, the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated.
这篇论文主要研究的是第i阶段临床试验中最大耐受剂量的估计问题。
Zhang Linqi to our correspondent, there are currently thousands of volunteers for more than 30 candidate AIDS vaccine Phase I of, II and Phase III clinical trials to assess.
张林琦曾向本刊记者介绍，目前全球已有成千上万名志愿者身上进行了30多个候选艾滋病疫苗的I期、II期和II I期临床试验评估。
Methods Retrospective review of transaminase data collected on placebo during 2 phase I clinical trials in 16 healthy volunteers, who were either hospitalized for 2 days or 13 days.
方法在2个新药I期临床试验中，对多次服用安慰剂、住院时间为2天或13天的16名健康志愿者多次进行转氨酶检查。
This paper summarizes studies for phase I clinical trials. It mainly introduces different, methods about determining maximum tolerated dose(MTD) and proposes further subjects for future research.
本文综述关于I期临床试验的研究。主要介绍确定最大耐受剂量（MTD）的不同方法，以及提出可以进一步进行研究的问题。
Studies on phase I clinical trials of artesunate tablet were carried out with double blind method in 22 male healthy volunteers.
以双盲法对22名健康男性志愿者进行青蒿琥酯片口服的耐受性和不良反应研究。
Studies on phase I clinical trials of artesunate tablet were carried out with double blind method in 22 male healthy volunteers.
以双盲法对22名健康男性志愿者进行青蒿琥酯片口服的耐受性和不良反应研究。
应用推荐