Phase I Trials of Molecularly Targeted Agents: Should We Pay More Attention to Late Toxicities?

分子靶向药物I期临床试验：我们更应多注重晚期毒性？

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On average, fewer than 5% of participants in phase I trials respond successfully to the treatment.

平均来说，在第一期试验中只有不到5%的参与者对于治疗反应良好。

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The real state of the world is that five anti-TB molecules are in phase I trials and two are in phase II.

事实情况是，有五种抗肺结核分子正处于试验阶段I，有两种处于试验阶段II。

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Almost all of these vaccines, however, are in Phase I clinical trials--early-stage tryouts meant to judge safety, not effectiveness.

FORBES: Magazine Article

The excitement over Canadian-based YM and its presentation of data from phase I and II clinical trials at ASCO centers not only on its positive data on myelofibrosis but on indications its JAK inhibitors may also have applications in solid tumors, as well as inflammatory diseases, says Chrystyna Bedrij, biotech analyst at Griffin Securities.

FORBES: YM Biosicences: Its Data at ASCO On Drug for Bone Marrow Disorders Catapults Its Stock

While other pharmaceutical companies have paid large amounts of cash for biotech drugs that had nearly completed human testing, Roche (otc: RHHBY - news - people ) has been sticking mostly to those that are in the earliest (phase I) or middle (phase II) stages of clinical trials.

FORBES: Roche Goes For Early Stage Biotechs