To avoid the extensive first-pass effect, intranasal administration is chose after reconstitution.
加水重建后，选择鼻粘膜给药途径以避免药物的首过效应。
参考来源 - 鼻粘膜给药尼莫地平冷冻干燥脂质体的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
Objective: To explore the first-pass effect in Small intestine.
目的：探讨小肠在首过效应中的作用。
The objective of this study was to develop a good absorbed and stable preparation that can avoid the strong first-pass effect of nimodipine (NMD).
本文旨在寻找制备一个吸收良好、稳定性好、可避免尼莫地平强的首过效应的制剂。
Documents show that the low biological activity of quercetin is due to its low bioavailability. Poor solubility and first-pass effect are the main factors that affect its bioavailability.
文献表明槲皮素生物活性低是由于其低的生物利用度，溶解性差与首过效应是影响其生物利用度的主要因素。
应用推荐