Because of a serious liver first-pass effect, the dosage forms of Naloxone Hydrochloride is mainly used on domestic and aboard clinical practice in the forms of injection and sublingual tablet.
但由于该药肝脏首过效应严重，口服无效，目前国内外临床上供应用的盐酸纳洛酮的剂型为注射液和舌下片。
ConclusionThe metabolism of DBDCT in rat liver microsomes was faster, suggesting that the liver first-pass effect of the drug may be stronger.
结论DBDCT在大鼠肝微粒体中代谢较快，提示该药可能肝首过效应较强。
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