Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

so it's like a very big change.

因为这意味着一个巨大的变化。

洛杉矶和纽约不一样 - SpeakingMax英语口语达人

It's a big change in some of these very poor villages to get a cow.

奶牛对这些赤贫的村庄来说可是生财之道

耶鲁公开课 - 金融市场课程节选

The only big change came in 1960 when they consolidated the ones around Paris, because of the growth of the Paris region, as you can see there.

仅在1960年由于巴黎区的发展,发生了一次改变,他们将巴黎周边的省进行合并,在这里可以看到

耶鲁公开课 - 1871年后的法国课程节选

So that's a big help. And equilibrium happens when there isn't any possible change of state that would satisfy this.

这个非常方便，当所有的变化,都无法满足这个公式的时候,系统就达到了平衡。

麻省理工公开课 - 热力学与动力学课程节选

That created a big constituency in favor of a dumb change. There was little warning.

这造就了一种悄无声息的变化,没有人提出警告。

斯坦福公开课 - 经济学课程节选

Changing the diet of populations is a pretty good idea and it's the kind of thing that could help individuals certainly lead healthier, happier lives, but also could change things like healthcare costs for a whole country, so these are big, big factors.

改变大众的饮食是个很好的想法,它不仅可以让人们过上更健康幸福的生活,还可以改变整个国家的医保费用,所以饮食是个非常非常重要的因素

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

The trouble is, you just don't know when that explosion took place, and since there are several periods in this general area that we're talking about now, in which something big happened, some great change takes place, it turns out different people want to have their explosion at different times.

问题是,你不了解火山爆发的,确切时间以及这种爆发,在这个区域又延续了很多个时期,这些时期发生了许多重大事件和重大变化,结果就是不同人对,火山爆发的时间推测各不相同

耶鲁公开课 - 古希腊历史简介课程节选

and go back to change the laundry over and pick it up, and it's really a big pain. It's really awful.

然后走回去把衣服拿出来，真是太痛苦了，真的很烦人。

与众不同的纽约 - SpeakingMax英语口语达人

The financial situation is not as bad as it was in the 1930s but it's getting bad and as a result we're starting to see proposals for big change.

现在的金融衍生工具已经不像当年那么拙劣了,但是它却开始走下坡路,所以最后的结果是,我们不得不准备着新的变革。

耶鲁公开课 - 金融市场课程节选