It was a big change in lifestyle when we moved to the country.

我们迁居到乡下，这在生活方式上是个巨大的变化。

《牛津词典》

When a whole school started to save food in their cafeteria, there was a big change.

当整个学校都开始节约食堂的食物时，会有巨大变化。

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That's a big change from the previous generation.

与上一代相比，这是一个巨大的变化。

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The researchers noted a big change in the list of countries with the lowest adult mortality over the past forty years.

VOA: special.2010.05.05

Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

so it's like a very big change.

因为这意味着一个巨大的变化。

洛杉矶和纽约不一样 - SpeakingMax英语口语达人

One big change is actually a change back with regard to the inspection of food imports.

NPR: Farm Bill Offers Aid to Fruit, Vegetable Growers

But here is the big change at Tesco, with which it is gradually coming to terms.

BBC: Will Tesco be deposed as retail king?

Another big change is the linking of the blue badge scheme to the new Pip payments.

BBC: Blue badge disabled parking to be extended in Wales