• An example is production of certain molecules called cytokines by T-cells that activate themselves.

    细胞能分泌这类叫做细胞因子的分子,实现自激活

    耶鲁公开课 - 生物医学工程探索课程节选

  • Now, t-cells are also involved in humoral immunity but they're not the end result.

    细胞也参与体液免疫,但它并不是体液免疫的最终应答结果

    耶鲁公开课 - 生物医学工程探索课程节选

  • Now that's going to be important when we talk about making human gene - making human proteins inside alternate hosts like bacteria, that they can't do all the things that your cells can do.

    这一步骤在我们谈到,利用像细菌那样的宿主,来生成人类蛋白时非常重要,因为细菌并不具备人类细胞的全部功能

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  • When these CD8 T-cells see your MHC1 together with an antigen that doesn't belong in you, it creates an immune response.

    当CD8 T细胞识别MHC1时,同时识别了不属于你的抗原,由此产生免疫反应

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  • So, the classes of T-cells: macrophages, natural killer cells, these are a class of cells that's particularly important called dendritic cells.

    这类T淋巴细胞包括巨噬细胞,自然杀伤细胞等 统称为树突细胞,树突细胞尤为重要

    耶鲁公开课 - 生物医学工程探索课程节选

  • The main effector cells in cell mediated immunity, the cells that do the main business are called T-cells.

    细胞免疫中的主要效应细胞,即发挥主要作用的细胞是T细胞

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  • Helper cells don't become cytotoxic cells but they help B cells become antigen producing - antibody producing cells.

    附助细胞不会成为细胞毒细胞,它们帮助B细胞成为抗体分泌细胞

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  • The antigen has to be presented to helper T-cells, those helper T-cells have to stimulate a B-cell population to both proliferate and differentiate.

    抗原需要被呈递给辅助性T细胞,这些辅助性T细胞需要激活B淋巴细胞,使其增殖和分化

    耶鲁公开课 - 生物医学工程探索课程节选

  • The immune system, some cells of the immune system, in particular this class of T-cells called CD8 cells have receptors which recognize MHC1.

    免疫系统,其中一些免疫细胞,特别是T细胞中的,CD8细胞含有可识别MHC1的受体

    耶鲁公开课 - 生物医学工程探索课程节选

  • So, that's antigen presentation to this population of cells called cytotoxic T-cells, Tc, a subset of the class of T-cells in the immune system.

    这些细胞被呈递给另一种细胞,这些细胞被称为细胞毒性T细胞,是免疫系统中T淋巴细胞的亚群中的一种

    耶鲁公开课 - 生物医学工程探索课程节选

  • Another subset of T-cells called T helper cells will recognize that signal by direct contact with it, and they will become activated and proliferate.

    另外一个T细胞的亚群是辅助性T细胞,辅助性T细胞可识别与其接触的抗原信号,并被激活,开始增殖

    耶鲁公开课 - 生物医学工程探索课程节选

  • In this case here, you're generating host cells, cytotoxic T-cells, that can kill only very specific cells, cells that are expressing this foreign antigen.

    而在这个例子中,人产生宿主细胞,即细胞毒性T细胞,它只会消灭特定的细胞,也就是携带特定异己抗原的细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • Because it has MHC-1, your MHC-1 on it, this T-cell recognizes that it's one of your cells but it has a foreign antigen associated with it.

    因为该细胞上有MHC-1,T细胞将这些细胞识别为自身细胞,但这些细胞带有异己抗原

    耶鲁公开课 - 生物医学工程探索课程节选

  • Here's where the intelligence of the immune system comes in, is that these cytotoxic T-cells that are generated only kill cells that have this signal on it.

    免疫系统的聪明之处就在此,这些细胞毒T细胞,只能杀死具有特殊标记信号的细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • They become activated and they produce, eventually, mature cytotoxic T-cells in large numbers.

    细胞毒性T细胞活化后,开始增殖,最终,产生大量成熟的细胞毒性T细胞

    耶鲁公开课 - 生物医学工程探索课程节选

  • Now, these Th-cells, helper T-cells, go on to stimulate B-cells, and it's these B-cells that become the mature antibody producing cells that make quantities of antibody that fill up in your body.

    这些辅助性T细胞,进一步刺激B淋巴细胞,从而使这些B淋巴细胞,逐渐发育成成熟的抗体生成细胞,可在体内产生大量抗体

    耶鲁公开课 - 生物医学工程探索课程节选

  • So, either stimulates the production of-- and differentiation of B-cells, to produce a specific antibody that can neutralize the virus, or stimulates the production of cytotoxic T-cells that can kill infected cells within your body.

    所以,疫苗的刺激要么能够,促进B淋巴细胞产生和分化,以生成特定的抗体来杀灭病毒,要么刺激T细胞释放细胞毒素,杀死身体里被感染的细胞

    耶鲁公开课 - 生物医学工程探索课程节选

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