Researchers at Duke University sifted through more than and found an absence of strong evidence that any of these approaches can make a big difference.

VOA: standard.2010.06.17

But whether or not you do so doesn't seem to make a big difference.

但不论你是否选择这样做,都不会有什么太大的影响

耶鲁公开课 - 心理学导论课程节选

Primarily the people who started are Emerson and Moscovici and many others who have done research showing how minority-- very often one person can make a big difference, can make a significant difference.

爱默生和莫斯科维奇是先驱,他们和其他学者都证明少数人-,经常是一个人，如何实现重大改变，能实现显著的改变。

哈佛公开课 - 幸福课课程节选

He says helping just one youth can make a big difference.

VOA: standard.2010.04.29

This water pump -- called the Super Money Maker -- is designed to make a big difference in the lives of rural Africans.

VOA: standard.2010.08.09