Researchers at Duke University scrutinized more than 160 published studies and found an absence of strong evidence that any of these approaches can make a big difference.

杜克大学的研究人员详细核查了160多项已发表的研究，发现并没有强有力的证据表明这些方法中的任意之一能产生重大作用。

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Your choice of words can make a big difference, too.

你的用词也会产生很大的影响。

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Even a few hours a month can make a big difference in someone's life.

即使是一个月几个小时，也会对一个人的生活产生很大的影响。

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A few degrees can make a big difference when it comes to food storage.

VOA: special.2009.02.09

But whether or not you do so doesn't seem to make a big difference.

但不论你是否选择这样做,都不会有什么太大的影响

耶鲁公开课 - 心理学导论课程节选

Primarily the people who started are Emerson and Moscovici and many others who have done research showing how minority-- very often one person can make a big difference, can make a significant difference.

爱默生和莫斯科维奇是先驱,他们和其他学者都证明少数人-,经常是一个人，如何实现重大改变，能实现显著的改变。

哈佛公开课 - 幸福课课程节选

But if you are designing a collaborative session, it can make a big difference.

FORBES: Want Collaboration? Watch Where You Sit.

And that decision can make a big difference in the eventual size of your nest egg.

FORBES: Back To The Future: Rethinking Retirement

But for knowledge workers whose jobs involve collaboration, the right technology can make a big difference.

FORBES: Make Your Workers Happy: Let Them Use Their Own Devices