The document was like the Constitution of the United States, but with major changes.

VOA: special.2009.07.23

There have been major changes of course in the food supply.

食品供应的进程经历了许多重大变革

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

Or make major changes in an activity that has already begun.

VOA: special.2009.07.12

Geithner says there are many signs the economy is recovering, but he says there is still a need for major changes by many nations, including the United States.

VOA: standard.2009.09.25

And even in the conservative grain-farming states, two hundred thousand farmers joined a group that called for major economic changes.

VOA: special.2010.12.09