They found the cancer cells of mother and baby carried the identical mutated cancer gene (called BCR-ABL1), but the infant had not inherited this gene.
他们发现母亲和婴儿的癌细胞携带有相同的突变癌基因（被称为BCR-ABL1），但是婴儿并没有得到这种基因的遗传。
But Gleevac, too, can be bypassed by further mutations of BCR-ABL which allow the tumour cells to grow in the presence of the drug.
但它无法阻止BCR - ABL产生进一步变异后的编码蛋白，即使在用药情况下肿瘤细胞仍不断扩张。
There is already a targeted treatment for this disease. Gleevec, probably the most remarkable anti-cancer drug of the past decade, disables the protein encoded by another fused gene, BCR-ABL.
现在对这种病已有针对性疗法，Gleevec大体是过去十年中效果最显著的药物，它能使另一融合基因BCR-ABL的编码蛋白失去活性。
Interestingly, BCR signaling could be reactivated in the defective cells, indicating that BCR signaling was not altogether absent but somehow suppressed.
令人感兴趣的是，在这些缺陷细胞中bcr信号可能重新活化，提示BCR信号不是一起缺乏而是有些被抑制了。
Objective:To study on relationship between of BCR/ABL fusion gene expression and TCM syndrome classification in the patient of chronic myelogenous leukemia(CML).
目的：探讨慢性粒细胞白血病（CML）患者BCR/ABL融合基因表达与中医辨证分型的关系。
In addition to representing a potential biomarker, the existence of cells with defective BCR signaling may provide new targets against follicular lymphoma. -jcl.
除了代表潜在的生物标记物外，伴有缺陷BCR信号的细胞存在可提供滤泡性淋巴瘤新的靶点。
The tyrosine kinases expressed by BCR-ABL fusion gene can cause cell proliferation, adhesion and survival natural change, several kinds of tumors can be caused by it.
BCR -ABL融合基因表达出的酪氨酸激酶能引起细胞增殖、黏附和生存性质的改变，导致多种肿瘤的产生。
Inhibiting BCR-ABL tyrosine kinases can impede the growing progress of tumors.
抑制BCR - ABL酪氨酸激酶可有效抑制肿瘤生长。
This paper introduces the first, second and some new BCR-ABL tyrosine kinases inhibitors.
本文介绍了第一、二代以及新近开发的BCR - ABL酪氨酸激酶抑制剂。
In BCR-ABL fusion gene negative myeloproliferative diseases, the discovery of JAK2V617F point mutation is an important landmark.
在BCR - ABL阴性的骨髓增殖性疾病的发病机制中，JAK2V 617 F点突变的发现是一个重大的突破。
These implied that the expression of BCR/ABL gene was related to the active proliferation of bone marrow cells.
结合各例骨髓增生活跃程度，表明BCR/ABL基因表达水平可以反映治疗效果。
Objective Evaluation the resistance of Rattus norvegicus against warfarin and bromadiolone and comparison the two testing methods, blood clotting response(BCR) and feeding.
目的测定褐家鼠的抗药性水平，比较凝血反应与摄食实验测定结果的差异。
There are other types of CML that do not involve the BCR-ABL gene.
相关疾病还有一些不涉及BCR-ABL基因的其它类型的慢性粒细胞白血病。
Results The higher valuable the equipments are, the more fixed cost they have with lower BCR.
结果：价格高的设备，固定成本也高，其成本效益比偏低。
If STI571 inhibits the BCR-ABL kinase so effectively, what is the result of its inhibition of the ABL kinase in normal cells?
如果STI571可高效地抑制BCR - ABL激酶活性，那它对正常细胞的ABL激酶的抑制会产生什么结果呢？
Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?
选择最佳的二线酪氨酸激酶抑制剂治疗伊马替尼治疗失败的慢性粒细胞白细胞患者：BCR - ABL突变状态是否真的重要？
ABL and BCR, which are located on chromosomes 9 and 22, respectively, are normal genes whose function is still unknown.
而ABL和BCR都是正常基因，分别定位于第9和第22号染色体，但它们的功能目前还不清楚。
Conclusion: detection of BCR-ABL fusion gene by one step RT-PCR has excellent sensitivity and specificity. The method is simple and rapid, and is exactly used to clinic detection.
结论：一步法rt - P CR检测BCR - ABL融合基因有很好的灵敏度和特异性，操作简便、快速，特别适用于临床检测。
Methods: to read the related literatures then to review and comment the B lymphocyte development and BCR gene rearrangement.
方法：通过相关文献的阅读，综合评述B细胞发育与BCR基因重排。
CONCLUSION: PMA and BCR-ABL chimeric gene can influence the expression of EDAG gene in leukemia cell line K562.
结论：诱导剂佛波酯和BCR - ABL嵌合基因可以影响EDAG基因在白血病细胞系k562中的表达。
Results:The expression signals of BCR/ABL fusion gene were dark violet-blue or brown precipitates.
结果 ：BCR/ABL融合基因表达信号为深紫 蓝色或棕色沉淀。
Given herein is how to determine the direction of formation stress, effective fractures and its strike according to BCR data from DSI Dipole Shear Sonic...
给出了利用斯伦贝谢公司偶极横波成像(dsi)的BCR资料来确定地应力方向和识别有效裂缝及其走向的实例。
The heavy metals forms of coal waste were analyzed by using of BCR method and the release characteristics of heavy metals were revealed by using of the United States TCLP, ASTM, and SPLP method.
利用改进的欧共体参比司（BCR）法分析了煤矸石重金属赋存形态，并利用美国TCLP、ASTM、SPLP等静态淋溶法和野外动态淋溶法研究了重金属的释放特性。
Conclusion: B lymphocyte development and BCR gene rearrangement is an ordered sequence. However, a lot of events in this procedure are unclear.
结论：B细胞发育及BCR基因重排是一个密切相关的十分有序的过程，但仍有许多问题未弄清楚。
An ultrasound bath extraction technique was applied in the modified BCR sequential extraction method for lead speciation in sediments.
研究了超声波水浴提BCR顺序提取法在铅形态分析中的应用，优化了水系沉积物样品铅的各分步提取时间。
An ultrasound bath extraction technique was applied in the modified BCR sequential extraction method for lead speciation in sediments.
研究了超声波水浴提BCR顺序提取法在铅形态分析中的应用，优化了水系沉积物样品铅的各分步提取时间。
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