It took advantage of X-ray crystallography that charted the precise three-dimensional structure of how Gleevec binds to Bcr-Abl.
FORBES: The Race Is On
The research shows that the protein produced by BCR-ABL1 is necessary to trigger and maintain the cancer, the scientists said.
BBC: Leukaemia 'on-off switch' discovered
The first being that you need to repeat this over and over during the treatment, very much like BCR-ABL. The second being that this technique has incredible low upstream and downstream processing and goes directly for the target.
FORBES: Gene Test For Pfizer Cancer Drug To Cost $1,500 Per Patient
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