They found the cancer cells of mother and baby carried the identical mutated cancer gene (called BCR-ABL1), but the infant had not inherited this gene.

他们发现母亲和婴儿的癌细胞携带有相同的突变癌基因（被称为BCR-ABL1），但是婴儿并没有得到这种基因的遗传。

youdao

But Gleevac, too, can be bypassed by further mutations of BCR-ABL which allow the tumour cells to grow in the presence of the drug.

但它无法阻止BCR - ABL产生进一步变异后的编码蛋白，即使在用药情况下肿瘤细胞仍不断扩张。

youdao

There is already a targeted treatment for this disease. Gleevec, probably the most remarkable anti-cancer drug of the past decade, disables the protein encoded by another fused gene, BCR-ABL.

现在对这种病已有针对性疗法，Gleevec大体是过去十年中效果最显著的药物，它能使另一融合基因BCR-ABL的编码蛋白失去活性。

youdao

It took advantage of X-ray crystallography that charted the precise three-dimensional structure of how Gleevec binds to Bcr-Abl.

FORBES: The Race Is On

The research shows that the protein produced by BCR-ABL1 is necessary to trigger and maintain the cancer, the scientists said.

BBC: Leukaemia 'on-off switch' discovered

The first being that you need to repeat this over and over during the treatment, very much like BCR-ABL. The second being that this technique has incredible low upstream and downstream processing and goes directly for the target.

FORBES: Gene Test For Pfizer Cancer Drug To Cost $1,500 Per Patient