At Michelle Cedillo's hearing last year, Dr. Marcel Kinsbourne, a pediatric neurologist who is a professor at The New School in New York, testified that he thought the measles vaccine was a "substantial factor" in causing the girl's autism.

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Trading for close to 10x sales per share means that the market has already priced-in a substantial growth factor.

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Nvidia cited Tegra 2 weakness as one factor for its substantial revenue softness.

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Another factor that boosts LM Ericsson in Christy's eyes is its substantial exposure to emerging markets, which are also avid consumers of wireless services.

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However, the bank's projections already factor in Labour's plans for fiscal tightening, which are quite substantial.

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Factor in waning supplies from recycled Russian nuclear warheads, which make up a substantial portion of world uranium reserves, and there is a clear need for new supply.

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Although demand for the single was not as high around the rest of the UK, Castaldo said "it was still clearly substantial, and it would have needed to be for the song to overtake an X Factor single".

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