阿司咪唑（astemizole）化学名为1-[(4-氟苯基)-甲基]-N-[1-[2-(4-甲氧苯基)乙基]哌啶-4-基]-1H-苯并咪唑-2-胺，白色粉末，分子式为C28H31FN4O，分子量为458.57000，密度为1.2 g/cm3，熔点为172.9ºC，沸点为627.3ºC at 760 mmHg。临床上主要治疗常年性和季节性过敏性鼻炎、过敏性结膜炎、慢性荨麻疹和其他过敏性反应症状及体征。
n. astemizole
阿司咪唑上市后心血管系统安全性评价 关键词：阿司咪唑；心脏毒性；上市后药物安全性监测 [gap=508]Key words：astemizole；cardiotoxicity；post marked monitoring of drug
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... 盐酸洛哌丁胺Loperamide Hydrochloride 阿司咪唑Lappaconite Hydrobromide 丙酸氯倍他索Clobetasol Propionate ...
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3. All the cases involved had not taken antihistamines for three days, astemizole for one month, or drugs that could affect immunological function for two months such as corticosteroids and immunosuppressive agent, et al.
近2个月内未用皮质类固醇激素或免疫抑制剂等影响全身免疫功能的药物。 1个月内未服用息斯敏(阿司咪唑),1周内未使用抗组胺药者。
参考来源 - 慢性荨麻疹患者转录因子T·2,447,543篇论文数据，部分数据来源于NoteExpress
方法用不同剂量的阿司咪唑对小鼠灌胃，分别记录不同时间的心电图变化。
METHOD Recording the ECG of mice in different time after they were admistrated with astemizole in different dose in different time.
结论：西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。
CONCLUSION: the effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole.
结果阿司咪唑使多数小鼠心率减慢，P R间期和Q T间期延长，随剂量增加，甚至可引起完全性房室传导阻滞和窦性停搏。
RESULTS astemizole could slower the heart rate of mice, prolong P-R and Q-T interphase, even arise the complete AV block and sinus beat stop with the dose increase.
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