阿司咪唑上市后心血管系统安全性评价 关键词：阿司咪唑；心脏毒性；上市后药物安全性监测 [gap=508]Key words：astemizole；cardiotoxicity；post marked monitoring of drug
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服一片息斯敏(Astemizole)或扑尔敏，很快就会恶化。一晃神，一转眼．我们就这样垂垂老去． 头痛(Headache)： 原故可以是慢性鼻炎、呛水或身段严寒、暂时...
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Astemizole Tablets 阿司咪唑片
Astemizole Suspension 阿司咪唑混悬液
Astemizole related 息斯敏相关
Astemizole standard 息斯敏标准品
3. All the cases involved had not taken antihistamines for three days, astemizole for one month, or drugs that could affect immunological function for two months such as corticosteroids and immunosuppressive agent, et al.
近2个月内未用皮质类固醇激素或免疫抑制剂等影响全身免疫功能的药物。 1个月内未服用息斯敏(阿司咪唑),1周内未使用抗组胺药者。
参考来源 - 慢性荨麻疹患者转录因子T·2,447,543篇论文数据，部分数据来源于NoteExpress
METHOD Recording the ECG of mice in different time after they were admistrated with astemizole in different dose in different time.
方法用不同剂量的阿司咪唑对小鼠灌胃，分别记录不同时间的心电图变化。
CONCLUSION: the effect of cetirizine in treating perennial allergic rhinitis is faster and the adverse reaction is less than those of astemizole.
结论：西替利嗪治疗常年变应性鼻炎与阿司咪唑比较具有起效快、不良反应少的特点。
RESULTS astemizole could slower the heart rate of mice, prolong P-R and Q-T interphase, even arise the complete AV block and sinus beat stop with the dose increase.
结果阿司咪唑使多数小鼠心率减慢，P R间期和Q T间期延长，随剂量增加，甚至可引起完全性房室传导阻滞和窦性停搏。
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