木糖醇作为一种产品最先是19世纪在芬兰从桦树上提取的，之后作为不影响糖尿病患者胰岛素分泌的安全甜味剂而在欧洲普及。

Xylitol as a product was first derived from Birch trees in Finland in the 19th century and was popularized in Europe as a safe sweetener for diabetics that would not impact insulin levels.

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高血压和受损的胰岛素敏感性是糖尿病的两个主要危险因素；通过每日一剂量的黑巧克力二者发生几率可以被降低。

Hypertension and impaired insulin sensitivity are two major risk factors for diabetes; both have been shown to be decreased by a daily dose of dark chocolate.

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咖啡含抗氧化剂，其中包括一系列圭宁的混合物。 通过对实验室的老鼠进行试验调查表明，它们能增加老鼠对胰岛素的敏感性。

"Coffee is loaded with antioxidants, including a group of compounds called quinines that when administered to lab rats, increases their insulin sensitivity\" he tells WebMD.

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Now, sometimes the agonist is the natural ligand itself and that's - an example of that is when you use insulin as a drug.

有时激动剂药物就是天然配体分子,例如将胰岛素作为药物使用

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We've identified many drugs that stimulate insulin receptors, for example, but they're not exactly insulin, and those can potentially be used as agonist type drugs.

我们已经设计了很多,能够激活胰岛素受体的药物,但它们都不是和胰岛素分毫不差的,但都可以用作激动剂类药物

耶鲁公开课 - 生物医学工程探索课程节选