Tsimberidou博士和她的同事挑选了患有晚期癌症的志愿者(这些患者的肿瘤是由单一的、已知的突变引起的)，试验方法与第一期相同。

Dr Tsimberidou and her colleagues selected volunteers with late-stage cancer whose tumours were caused by single, known mutations and did the equivalent of a phase I trial on them.

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格鲁夫发现，在最近的500万年期间，全球平均气温发生过三次突变。

Grove found that the mean temperature changed suddenly on three occasions during the last 5 million years.

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他们表示，越来越多的证据证实损伤，以及下一代畸形和基因突变的风险，其中包括儿童期癌症以及不育。

They say that growing evidence links the damage with the risks of defects and mutations in offspring, including childhood cancer and infertility.

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