Tsimberidou博士和她的同事挑选了患有晚期癌症的志愿者(这些患者的肿瘤是由单一的、已知的突变引起的)，试验方法与第一期相同。
Dr Tsimberidou and her colleagues selected volunteers with late-stage cancer whose tumours were caused by single, known mutations and did the equivalent of a phase I trial on them.
格鲁夫发现，在最近的500万年期间，全球平均气温发生过三次突变。
Grove found that the mean temperature changed suddenly on three occasions during the last 5 million years.
他们表示，越来越多的证据证实损伤，以及下一代畸形和基因突变的风险，其中包括儿童期癌症以及不育。
They say that growing evidence links the damage with the risks of defects and mutations in offspring, including childhood cancer and infertility.
目的：探讨ABCB4基因外显子23点突变与妊娠期肝内胆汁淤积症（ICP）发病的关系。
Objective To investigate the relationship between the point mutation of ABCB4 gene exon 23 and the intrahepatic cholestasis of pregnancy (ICP).
抗病突变体大多伴随着株高、熟期、育性或粒重等农艺性状的变异。
These mutants were almost accompanied by variations in agronomic traits such as dwarfism, high sterility, heading date or grain weight.
【译】KRAS基因密码子12和13与无病生存的野生型BRAF的II I期结肠癌辅助化疗试验从一个突变(n0147联盟)。
KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild type stage III colon cancers from an adjuvant chemotherapy trial (N0147 Alliance).
EMS诱变产生的主要突变类型有：穗部形态突变、籽粒形态突变、茎秆形态突变、叶片性状突变、育性突变及熟期突变等。
The main mutant-types induced by EMS were ear visibles, seed visibles, stem visibles, leaf character mutation, fertility mutation and mature period mutation.
突变株系增产的主要原因可能是孕穗灌浆期净光合速率和表观量子效率的急剧增加。
The higher grain yield in mutated strains was mainly due to abundant carbohydrate synthesis and transfer to grains during booting-filling stage .
目的探讨某地区丰水期的饮用水及水源水的致突变性。
Objective To approach the mutagenicity of drinking water and source water in plentiful phase of the region.
孕穗-灌浆期的净光合速率和表观量子效率的急剧增加可能成为突变株系增产的主要原因。
The higher grain yield in mutated strains was mainly due to increasing the net photosynthetic rate and apparent quantum yield considerably at the stage from booting to filling.
在相同种植条件下，低纤维基因突变体选育的嫩稻表现出较强的营养体生长优势，收获期叶、鞘、茎生物产量分别较亲本提高27.77%、30.19%和37.96%。
Compared with parental rice, LF rice showed an advantage in its vegetative growth and the yields of leaf, sheath and stem increased by 27.77%, 30.19% and 37.96% respectively.
目的探讨某地区丰水期和枯水期的饮用水及水源水的致突变性。
Objective To approach the mutagenicity of drinking water and source water in plentiful phase and in exhausted phase in the region.
一旦它的一个碱基发生突变，就可使线虫永远停留在幼虫期，而无法成熟。
Once one of its base mutation, would enable the nematodes remaining in the larval stage, and can not mature.
突变分析表明，豫西烟区烤烟生育期的日照时数在1981年发生突变。
Mutation analysis showed that the saltation of sunshine durations at tobacco growth period in western Henan occurred in 1981.
该突变体的病斑在全生育期均表现，属于扩散型类病斑突变体。
The mutant displayed lesion mimic in its whole life, and belonged to propagation type.
目的：探讨ABCB 4基因点突变与妊娠期肝内胆汁淤积症(ICP)发病的关系。
AIM: To investigate the relationship between the point mutation of ABCB4 gene and intrahepatic cholestasis of pregnancy (ICP).
这些突变通过增加心舒张期SRCa2 +的漏出引起触发性心律失常。
These mutations may cause triggered arrhythmias by enhanced diastolic SR Ca2 + leak.
该突变体苗期表型正常，分蘖期株型松散，分蘖角度较野生型显著增大，株高明显降低。
At the seedling stage, tac2 displayed normal phenotype and its tiller Angle significantly increased at the tillering stage compared with wild type.
该突变体苗期表型正常，分蘖期株型松散，分蘖角度较野生型显著增大，株高明显降低。
At the seedling stage, tac2 displayed normal phenotype and its tiller Angle significantly increased at the tillering stage compared with wild type.
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