It suggested that the LDL receptor in human fetal liver may play a key role in the regulation of the serum cholesterol levels in the fetus during gestation.

这一结果提示，在胎儿发育过程中，肝脏ldl受体对血胆固醇水平调节起着关键的作用。

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To understand intron 15 of human LDL receptor gene, the DNA fragments from exon 15 to exon 16 and the 3' end of intron 15 were amplified with long chain PCR and anchored PCR.

为了解人类LDL受体基因内含子15的遗传背景，利用长链PCR和锚定PCR分离了LDL受体基因外显子15-内含子15-外显子16和内含于15的3’末端片段。

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Conclusion: HGF can up-regulate expression of LDL receptor in mesangial cells and increase mesangial cells uptake of LDL, so HGF may play a role in lipid-induced kidney injury.

结论：HGF通过促进系膜细胞表达LDL受体，增加系膜细胞对LDL的摄取，可能参与了脂质肾损伤过程。

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Previous estimates said there were only 400 HoFH patients in the U.S. but included only those people confirmed to have two defective copies of the LDL receptor gene.

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