采用单因素、正交设计方法，以凝胶的稳定性和体外释放情况筛选了鼻用凝胶剂的基质和附加剂，确定了凝胶剂的最终制剂处方和制备方法；

Single combination of factors orthogonal design method to gel stability and in vitro release of the screening matrix and additives, determine the final gel formulations recipe and preparation method;

youdao

这种温敏凝胶剂除了具有一般鼻用制剂的优点以外，还可以明显延长药物在鼻腔的滞留时间。

Thermosensible gel formulation can prolong the nasal residence time of drug greatly except for the merits of traditional nasal preparation.

youdao