采用单因素、正交设计方法，以凝胶的稳定性和体外释放情况筛选了鼻用凝胶剂的基质和附加剂，确定了凝胶剂的最终制剂处方和制备方法；

Single combination of factors orthogonal design method to gel stability and in vitro release of the screening matrix and additives, determine the final gel formulations recipe and preparation method;

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这种温敏凝胶剂除了具有一般鼻用制剂的优点以外，还可以明显延长药物在鼻腔的滞留时间。

Thermosensible gel formulation can prolong the nasal residence time of drug greatly except for the merits of traditional nasal preparation.

youdao

这种温敏凝胶剂除了具有一般鼻用制剂的优点以外，还可以明显延长药物在鼻腔的滞留时间。

Thermosensible gel formulation can prolong the nasal residence time of drug greatly except for the merits of traditional nasal preparation.

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