基因在受体动物的基因组中随机整合，严重制约了转基因动物外源基因的稳定遗传，是转基因动物研究亟待解决的问题。

The random integration in receptor genome has restricted heredity stabilization of target gene in transgenic animals. It's the key problem which should be solved in the study of transgenic animals.

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由于生产转基因动物的基本方法如原核注射法等普遍存在外源基因整合的低效性和随机性等问题，因而在应用中受到很大制约。

The basic reliable methods available to produce transgenic animal such as pronuclear microinjection has limited application by low efficiency and mosaic integration into the genome.

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使用固定与随机效果模型整合资料。

Fixed and random effects models were used to pool the data.

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