基因在受体动物的基因组中随机整合，严重制约了转基因动物外源基因的稳定遗传，是转基因动物研究亟待解决的问题。
The random integration in receptor genome has restricted heredity stabilization of target gene in transgenic animals. It's the key problem which should be solved in the study of transgenic animals.
由于生产转基因动物的基本方法如原核注射法等普遍存在外源基因整合的低效性和随机性等问题，因而在应用中受到很大制约。
The basic reliable methods available to produce transgenic animal such as pronuclear microinjection has limited application by low efficiency and mosaic integration into the genome.
使用固定与随机效果模型整合资料。
结论证实了转基因动物导入外源性基因整合位点是随机的；整合位点引起的肿瘤可以随着细胞发育的不同阶段，逐渐的显现。
It is proved that the conformity site of exogenous gene in APP transgenic mice is random, the tumor induced by gene conformity site could manifest with different stage of cell growing.
随机分为实验组和对照组，实验组予补骨合剂灌胃，分别于术后1、2、4、8、1 2周取出标本进行种植体—骨界面骨整合情况观察。
The dogs of experimental group were ingested with BGC. The implanted maxillofacial part were sampled to observe the changes of implant-bone interface immedately 1,2,4,8,12 week after the surgery.
随机分为实验组和对照组，实验组予补骨合剂灌胃，分别于术后1、2、4、8、1 2周取出标本进行种植体—骨界面骨整合情况观察。
The dogs of experimental group were ingested with BGC. The implanted maxillofacial part were sampled to observe the changes of implant-bone interface immedately 1,2,4,8,12 week after the surgery.
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