毫无疑问，近几十年来，制造业遭受了重大打击，而进一步的贸易协议引发了一些关于新的冲击是否会影响制造业的问题。
Without question, manufacturing has taken a significant hit during recent decades, and further trade deals raise questions about whether new shocks could hit manufacturing.
我们一直奋斗了很多年，看到一个新乐队在我们之前成功，这对我们是个重大打击。
We've been struggling for years and it's a real kick in the teeth to see a new band make it ahead of us.
上周她在谷歌高管名单中还名列第五，这是一个重大打击。
She was last week, number five on Google's exec list which is a huge blow.
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