毫无疑问，近几十年来，制造业遭受了重大打击，而进一步的贸易协议引发了一些关于新的冲击是否会影响制造业的问题。
Without question, manufacturing has taken a significant hit during recent decades, and further trade deals raise questions about whether new shocks could hit manufacturing.
我们一直奋斗了很多年，看到一个新乐队在我们之前成功，这对我们是个重大打击。
We've been struggling for years and it's a real kick in the teeth to see a new band make it ahead of us.
他们的话是对我自信心的一次重大打击。
你可以看任何重大打击目录，他们有他们的。
You can look in any major tackle catalog and they have them in it.
上周她在谷歌高管名单中还名列第五，这是一个重大打击。
She was last week, number five on Google's exec list which is a huge blow.
90年代末在面对一些系重大打击时，东盟显现出如此的无能为力。
In the late 1990s ASEAN was powerless in face of a series of blows.
这项协议也有望能从总体上对中国互联网上的侵犯版权现象给予重大打击。
It has also raised hopes that it could deal a significant blow to copyright infringement on the Chinese Internet overall.
在经历重大打击之后，明智的做法是勇敢面对挑战，而不是逃避。
What makes sense is to face the challenge rather than run away from the troubles after suffering a significant loss.
我感觉很糟糕，我每天都想起这件事，这对我的人生造成重大打击。
I feel so terrible, I think about it every day, it's had a massive impact on my life.
那么如果你们公司的唯一盈利来源是广告服务，那么你们的年利润将受到重大打击。
Now if your sole revenue source is advertising, then your revenue gets hit hard.
他们当然不像‘伟大社会’前那么可怕，但他们反映出对美洲大部分地区的重大打击。
They are certainly not as horrific as before the Great Society but they reflect a huge shock to large parts of America.
“收购一个如汇源的王牌企业将是对整个行业的重大打击。”他补充道。
"The acquisition of a flagship enterprise like Huiyuan would deal a heavy blow to the whole industry," he added.
这是对我们这样因全球经济萧条的影响而仍在蹒跚行步的公司一个重大打击。
It is a big blow to companies like ours still reeling from the effects of the global recession.
共和党已经开始审视自己，审问为什么这周将要进行的大选的预期会遭遇重大打击。
The Republican Party has already begun an inquest into what it expects will be a heavy defeat at the polls this week.
福岛核电厂还存在机械和化学上双重危险性，地震和海啸都有可能对它造成重大打击。
But there are still some vulnerabilities, both mechanical and chemical, that the earthquake and tsunami exploited in the Fukushima plant.
由于从俄罗斯危机的失误中汲取了教训，近10年来巴克莱资本几乎没有遭受重大打击。
Having learnt from the mistakes of the Russian crisis, BarCap went almost 10 years without any big blow-ups.
例如，不妨考虑一下将享受“老年医保”的年龄提高到67岁，对数百万美国人形成重大打击的议案。
Consider, for example, proposals to raise the age of Medicare eligibility to 67, dealing a major blow to millions of Americans.
这个爆炸消息对共和党竞选下月国会中期选举，并想以此控制白宫和参院，无疑是个重大打击。
The media circus threatens to overwhelm the Republican campaign for next month’s mid-term congressional elections, which look increasingly tight both in the House and in the Senate.
由于查狄伦是全队最重要的单位，失去你对全队实力和信心都是重大打击甚至丧失赢的机会。
Bat Chats are some of the most valuable assets you may have on your team, so losing one will be a major blow to your overall chances for victory.
在此期间，虽然也遭受到一些重大打击，但是我总是充满希望，乐观地相信我最终会事业有成。
Though I'd suffered some hard knocks, I was always hopeful and optimistic that I would, eventually, have a successful career.
该裁决对塞尔维亚来说是一个重大打击。 塞尔维亚一直要求国际法院对科索沃宣布独立给出意见。
That ruling came as a setback for Serbia, which had asked the International Court of Justice, the ICJ, to give an opinion on Kosovo's declaration.
这次事件是对艾滋病预防工作的重大打击，在过去15年间，该病的感染率已从2%降低到0.6%。
The outbreak is a serious blow to HIV prevention efforts. Over the past 15 years, the infection rate has dropped from 2 percent to 0.6 percent.
这次事件是对艾滋病预防工作的重大打击，在过去15年间，该病的感染率已从2%降低到0.6%。
The outbreak is a serious blow to HIV prevention efforts. Over the past 15 years, the infection rate has dropped from 2 percent to 0.6 percent.
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