肝坏死hepatonecrosis,hepatic necrosis 肝坏死由某一种或多种因素在一不定期时间内造成大量肝细胞损伤坏死，肝细胞细胞膜的完整性被破坏胞质膜破裂最后导致细胞溶解细胞内细胞器死亡胞质液中酶类释出。并不是整个肝脏都坏了
现已证明不同化学毒物引起肝坏死（hepatic necrosis）的区域不同，多数化学毒物引起肝小叶中央区坏死，如 CCl4，氟烷（halothane）等卤代烃。
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急性肝坏死 acute hepatic necrosis ; AHR ; AHN
大块肝坏死 massive hepatic necrosis
肝坏死杆菌病 liver necrobacillosis
多小叶性肝坏死 multilobular hepatic necrosis
亚急性肝坏死 subacute hepatic necrosis ; subacute liver necrosis
急性缺氧性肝坏死 acute anoxic hepatic necrosis
次广泛性肝坏死 submassive hepatic necrosis
急性免疫性肝坏死 acute immunity hepatic necrosis
中毒性肝病伴有肝坏死 Toxic liver disease with hepatic necrosis
Microscopic study shows that:The groups after operations showed necrosis and hyperplasia in hepatocyte,together with cholangiectasis and cholestasis in portal areas. And the hepatonecrosis were more obvious as the time passing.
光镜下检查显示手术各组均可见肝细胞坏死及增生,汇管区可见胆管扩张、胆汁淤积,肝坏死程度随手术后时间的延长而越发为重。
参考来源 - 大鼠梗阻性黄疸与细胞间粘附分子·2,447,543篇论文数据，部分数据来源于NoteExpress
方法：用脂多糖(LPS)诱发DHBV感染雏鸭急性肝坏死，建立实验模型。
Methods: An acute hepatic failure model was established in ducklings infected DHBV with lipopolysaccharides (LPS).
上述结果说明此模型与免疫异常有着密切关系，是研究肝坏死免疫发生机理的较理想模型。
These results strongly suggest that the abnormal immunity involved in the liver cell necrosis in the model.
另外，VPA对消化系统、肝脏及血液系统均有潜在的毒性作用，甚至出现致死性肝坏死。
In addition, VPA has potential toxicity for digestive system, blood system, and liver, even lethiferous putrescence.
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