包含这两个基因的信号通路的组成性激活，可能是导致葡萄膜黑色素瘤的主要因素。
Constitutive activation of the pathway involving these two genes appears to be a major contributor to the development of uveal melanoma. (Funded by the National Institutes of Health and others. ).
JAK2是一种组成性酪氨酸激酶，能激活JAK - STAT信号传导途径。
JAK2 is a constitutive protein tyrosine kinase (PTK) which can activate JAK-STAT signaling.
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