双特异抗体(Bispecific antibody)是含有两个不同配体结合位点的免疫球蛋白分子。自然状态下不存在双特异性抗体,只能通过特殊方法进行制备。
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构建四价形式的anti-CD3/anti-Pgp双功能抗体双功能抗体也称为双特异抗体(bispecific antibody,BsAb),其四价结构能够增加分子量和结合域,延长半衰期和增加结合力,间接延长抗体的作用时间。
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单链双特异抗体 single-chain bispecific antibody ; SCBSAB
探讨在双特异抗体 Bispecific antibody ; BIAB
双特异性抗体 bispecific antibody ; bispecific antibodies ; BSAB ; Bispecific Ab
双特异性单克隆抗体 Bispecific monoclonal antibody ; bispecific McAb ; bispecifity monoclonal anubody ; BSAB
的双特异性抗体 Bispecific antibody ; BSAB
抗肿瘤双特异性抗体 bispecific antibody ; BSAB
双特异单克隆抗体 Bs McAb
链双特异性抗体 BSAB ; Bispecificantibody
结论建立的双抗体夹心elisa检测MP抗原具有快速、简便、灵敏度高、特异性强等优点。
Conclusions Antibody-sandwich ELISA for detection of mp antigen is simple, rapid, sensitive and specific.
本发明描述了三官能双特异性抗体用于制备用来预防和治疗肿瘤疾病的药物组合物的应用。
The present invention describes the use of trifunctional bispecific antibodies for the preparation of a pharmaceutical composition for the prophylaxis and treatment of tumor diseases.
结果该双功能抗体与舌癌组织特异性结合率为85.29%，与血管内皮细胞结合率为82.35%。
Results: the specific conjugation rate between bifunctional antibody and lingual cancer tissue was 85.29%, and that between the antibody and vascular endothelial cells was 82.35%.
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