由于剂量率的影响，利用微核剂量效应曲线估算得到的剂量值，存在较大的不确定度，尤其进行低剂量估算时更明显；
The uncertainty of estimated dose by dose-effect curve is depending on the dose rate, especially, in the low dose range the influence is remarkable.
毒性实验存在随机误差，同时剂量-效应曲线（DRC）拟合也会产生误差。
Random error exists not only in toxicity experiments but also in the fitting of dose-response curves(DRC).
结论常用的药效学S型剂量效应曲线拟合的数学模型中，Hill系数无生理学含义。
CONCLUSION the Hill coefficient is considered not any physiological meanings in the mathematics model usually used in fitting pharmacodynamics s dose-effect curve.
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