切除修复 (excission repair):对多种DNA损伤包括碱基脱落形成的无碱基点、嘧啶二聚体、碱基烷基化、单链断裂等都能起修复作用。此系统是在几种酶的协同作用下,先在损伤的任一端打开磷酸二酯键,然后外切掉碱基或一段寡核苷酸;留下的缺口由修复性合成来填补,再由连接酶将其连接起来。不同的DNA损伤需要不同的特殊核酸内切酶来识别和切割。
核苷酸切除修复 nucleotide excision repair ; NER ; excision repair
碱基切除修复 Base excision repair ; DNA Base Excision RepairDNA ; BER ; base excise repair
基切除修复 base excision repair ; BER ; base excise repair
核苷酸切除修复途径 nucleotide excision repair ; NER
切除修复交叉互补基因 ERCC ; excision repair cross complementing ; excision repair cross complementation group
酸切除修复 GG-NER ; nucleotide excision repair ; NER
核苷酸切除修复系统 nucleotide excision repair ; NER
核切除修复基因 nuclear excision repair genes
核苷酸切除修复基因 Nucleotide excision repair gene
切除修复蛋白 excision repair cross complement ; ERCC
一种切除修复方法,通常用来修复经受了大的或不同寻常修饰的核苷酸。
A kind of excision repair usually used to fix nucleotides that have undergone large or unusual modifications.
背景与目的:研究碱基切除修复基因XRCC1基因G28152A单核苷酸多态与肺癌风险的关系。
BACKGROUND&AIM: To evaluate the correlation between the single nucleotide polymorphism of XRCC1gene G28152A and the risk of lung cancer.
已知细胞中DNA氧化性损伤主要通过碱基切除修复(BER)来完成,许多修复酶参与了这一修复过程。
The DNA oxidative damage is believed that it is repaired mainly by the base excision repair (BER) mechanism with many repairing enzymes.
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