国际呼吸杂志081001 关键词： 核苷酸切除修复基因;肺癌;易感性 [gap=1346]Keywords ：Nucleotide excision repair gene;Lung cancer;Susceptibility
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目的：探讨核苷酸切除修复基因ERCC1在肺癌中的表达及其与多环芳烃(PAH) - DNA加合物的关系。
AIM: To investigate the expression of nucleotide excision repair gene ERCC1 and its relationship with PAH (polycyclic aromatic hydrocarbons) -dna adducts in lung cancer tissues.
背景与目的：研究碱基切除修复基因XRCC1基因G28152A单核苷酸多态与肺癌风险的关系。
BACKGROUND&AIM: To evaluate the correlation between the single nucleotide polymorphism of XRCC1gene G28152A and the risk of lung cancer.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
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