这种药物主要是通过抑制切割酶来起作用的,并且在2007年夏天该药已开始临床试验了。
That drug, which works by inhibiting the cutting enzyme, began human clinical trials in the summer of 2007.
它们改变了这个酶切割淀粉样蛋白前体的方式。
目前发现的这个酶被命名为FAN1,它是一种核酸酶,能够切割开dna的核苷酸链。
The enzyme, which they named FAN1, appears to be a nuclease, which is capable of slicing through strands of DNA.
Cutting involves enzymes called restriction endonucleases or restriction enzymes, which I've already mentioned and they have names.
切割用到的酶叫限制性核酸内切酶,或限制性内切酶,我已经提到过了,而且它们都有名字
In this case, this particular restriction enzyme cuts symmetrically like this, but not at the same point.
在我们这种情况下,这个限制性内切酶总是这样对称地切割,但两条链切割的位点不一样
If this was a sickle patient, so they had this gene instead it wouldn't get cut and when I went to look for that presence of that gene on this gel, it would appear as one large segment instead of a large one and a smaller one.
而如果是个镰状红细胞贫血的病人,他们的基因是不会被限制酶切割的,因此他们基因的凝胶电泳结果就不会呈现,一大一小的结果,而只有一个大的片段
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