这真是最粗重、最让人疲惫不堪的工作了。

This was the heaviest and most fatiguing work of all.

《柯林斯英汉双解大词典》

显然，预期之外的噪音比预期到的更容易使人疲惫，只是这种疲惫要过一会才能在人的身上体现出来。

Apparently, unpredictable noise produces more fatigue than predictable noise, but it takes a while for this fatigue to take its toll on performance.

youdao

眼泪可以让一个人疲惫到一个程度。

Tears for a person to a degree of fatigue.

youdao

And everyone at the office would get really tired because they don't have their caffeine.

没补充咖啡因，在办公室的每个人都会感到疲惫。

Let's 实战 - SpeakingMax英语口语达人

the lonely, the happy, the successful, the tired... everyone here.

孤单的人、开心的人、成功的人、还有疲惫不堪的人……任何人都有。

美国贫富差距？ - SpeakingMax英语口语达人