Valproate was FDA-approved in 1995 for treatment of mania.

1995年，丙戌酸钠被FDA核准用于治疗躁狂。

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ABSTRACT Objective: To study the influence of sodium valproate on plasma fibrinogen.

目的：研究丙戊酸钠对血浆纤维蛋白原的影响。

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Children and adolescents with bipolar disorder generally are treated with lithium, but valproate and carbamazepine also are used.

儿童和青少年患者常使用锂盐治疗，但也使用丙戌酸钠和卡马西平。

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Both Sanofi and campaigners have advised women taking sodium valproate, not to stop anti-epileptic medications suddenly, without discussing their treatment with their doctor.

BBC: Sussex woman's fresh campaign over Epilim 'side-effects'

Half were given antiepileptic drugs carbamazepine or valproate immediately, while the other half did not receive any treatment until they and their clinician agreed it was necessary.

BBC: NEWS | Health | 'Watch and wait' seizure advice

Families involved in last year's legal action had claimed Epilim, or sodium valproate, caused a range of birth defects which they said included spina bifida, heart damage, learning difficulties and cleft palate.

BBC: Sussex woman's fresh campaign over Epilim 'side-effects'