Valproate was FDA-approved in 1995 for treatment of mania.
1995年，丙戌酸钠被FDA核准用于治疗躁狂。
ABSTRACT Objective: To study the influence of sodium valproate on plasma fibrinogen.
目的：研究丙戊酸钠对血浆纤维蛋白原的影响。
There were no significant differences between the levetiracetam and valproate groups.
左乙拉西坦组与丙戊酸钠组差异无统计学意义。
As a first - line agent for treating epilepsy, valproate sodium is widely used in clinic.
丙戊酸钠作为常用一线抗癫痫药，目前在临床的应用较为广泛。
The effects of the blood concentration weren't great on TPM to carbamazepine and valproate.
TPM对卡马西平及丙戊酸钠血药浓度影响不大。
Objetive the aim of this paper was to observe the clinical efficacy of valproate magnesium in mania.
目的探讨丙戊酸镁抗躁狂症的临床疗效。
OBJECTIVE to explore the pathogenesis of thrombocytopenic purpura caused by sodium valproate treatment.
目的探讨丙戊酸钠致血小板减少性紫癜可能发生机制。
Objective: to compared the pharmacokinetics of sodium valproate suppository with sodium valproate tablets.
目的：比较丙戊酸钠栓剂与片剂的药代动力学特征。
The higher the dosage of valproate a woman had taken, the lower the IQ of the child, the researchers found.
研究表明，一个妇女服用这种抗癫痫药物的剂量越高，他的孩子的智商越低。
AbstractObjectiveTo investigate the effects of valproate treatment on plasma insulin and leptin levels of epileptic children.
目的探讨丙戊酸治疗对癫疒间患儿血浆胰岛素和瘦素水平的影响。
Children and adolescents with bipolar disorder generally are treated with lithium, but valproate and carbamazepine also are used.
儿童和青少年患者常使用锂盐治疗，但也使用丙戌酸钠和卡马西平。
Rusults The blood drug concentration had no difference at the 3 points and no relationship with the history of taking Valproate.
结果术后不同时间检测病人的丙戊酸血药浓度无明显差异常， 术后血药浓度与术前病人是否服用丙戌酸制剂无关；
Methods To analyze the data of monotherapy with retard tablets of magnesium valproate in 86 cases of differentepileprtic seizure.
方法对86例应用丙戊酸镁缓释片治疗癫痫的患者资料进行回顾性分析。
Objective To investigate the clinical efficacy and side effects of sodium valproate in the treatment of alcohol withdrawal reaction.
目的探讨丙戊酸钠对酒精戒断反应的临床疗效及副反应。
No effects of risperidone on lithium or valproate exposure were observed, despite a 20% increase in valproate peak plasma concentration.
我们没有观察到利培酮合用锂盐或丙戊酸钠的不良反应，尽管在丙戊酸钠上血浆浓度峰值增加20%。
ConclusionBorneol can enhance the permeability of blood-brain barrier to sodium valproate, but has small influence on blood concentration.
结论冰片可提高血脑屏障对丙戊酸钠的通透性，但对血药浓度影响较小。
Objective To observe the effect of magnesium valproate sustained release tablets on children with epilepsy and its effects on cognitive function.
目的观察丙戊酸镁缓释剂治疗癫的疗效及其对癫患儿认知功能的影响。
Neither sodium valproate nor Verapamil showed any effect on action potential amplitude, overshoot, resting potential and phase o upstroke velocity.
丙戊酸钠和异搏定对动作电位幅度、超射值、静息电位、O期最大除极速度均无明显影响。
METHODS: the serum concentrations of valproate in 276 patients were determined by fluorescence polarization immunoassay and the results were analyzed.
方法：采用荧光偏振免疫法测定276例癫痫患者的丙戊酸血药浓度并分析结果。
ObjectiveTo investigate whether changes of insulin and leptin levels had a role in the weight gain associated with valproate acid in epileptic patients.
目的研究服用妥泰或丙戊酸的癫痫病人的体重改变是否与胰岛素和瘦素水平的改变有关。
Conclusion: Lower dose sodium valproate is effective in the treatment of TD caused by antipsychotics. Close attention should be paid to the platelet count.
结论：丙戊酸钠治疗抗精神病药所致TD有效，但以低剂量为宜，应注意监测血象。
AIM: To observe the effects of sodium valproate in the repair of rat sciatic nerve injury through the drug experiment of the model of sciatic nerve injury.
目的：通过对坐骨神经损伤模型的药物实验研究，观察丙戊酸钠对大鼠周围神经损伤的修复作用。
Objective: to evaluate the efficacy and side effects of sodium valproate and carbamazepine in the treatment of manic episodes refractory to lithium carbonate.
目的：评价丙戊酸钠与卡马西平对锂盐治疗无效的躁狂发作的疗效和副反应。
CONCLUSION: This HPLC-fluorescence method is quick, sensitive and economical, which can be used to monitor the concentration of sodium valproate in human serum.
结论：本检测方法快速、灵敏、经济，可用于监测人血清中丙戊酸钠的浓度。
That valproate exposure carries a higher risk of birth defectsthan other antiepileptics, such as lamotrigine and carbamazepine, is not new knowledge, Torbjorn Tomson, M.D.
暴露在丙戊酸钠下具有比其他抗癫痫药更高的出生缺陷，比如卡马西平和拉莫三秦。
Valproate acid had no influence on fasting serum insulin level of epileptic patients, but can increase their fasting serum leptin level, especially obese epileptic patients.
丙戊酸对癫痫病人空腹胰岛素水平无明显影响；可显著增加癫痫病人的空腹瘦素水平，尤其是肥胖病人。
The levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the serum of the rats administered sodium valproate alone were rasied significantly(P<0.05).
丙戊酸钠与五味子乙素联合应用，大鼠血清中天门冬氨酸转氨酶、谷丙转氨酶水平显著下降（P<0.05）。
CONCLUSION: in therapeutic drug monitoring of valproate, it should be concerned about the impact factors of valproate concentration to ensure the safety and efficacy in patients.
结论：在丙戊酸治疗药物监测中，要关注影响丙戊酸血药浓度的因素，确保患者用药安全有效。
All rats were randomly divided into six groups: KXZZ high-does group, KXZZ middle-does group, KXZZ low-does group, valproate magnesium group, model group and normal control group.
实验大鼠随机分为中药高剂量组、中药中剂量组、中药低剂量组、丙戊酸镁组、模型组、正常对照组。 观察各组大鼠的惊厥潜伏期；
Methods: Seizures in the group of epileptic rats induced by penicillin, the group of the LTG, and the group of the sodium valproate were measured, and the EEG was recorded for the groups.
方法：观察青霉素致痫组、拉莫三嗪组、丙戊酸钠组大鼠痫性发作，并记录其脑电图。
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