非小细胞肺癌TRF1的表达及核定位信号序列检测 端时,端粒酶得以将端粒重复序列TTAGGG加到端粒末端,造成细胞不朝衰老、死亡方向运动,而引起肿瘤.端粒重复序列结合因子(TelomericRepeatBindingFactor1,TRF1)就是端粒结合蛋白的一种,TRF1由439个氨基酸组成,分子量约60KD,研究结果表明TRF1是端粒延
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This C terminus domain dependent interaction between P53 and TRF1, TRF2 may be related to the cellular activities induced by telomere dynamic changing.
P5 3和TRF1、TRF2这种结构域依赖性的结合可能与端粒动态变化所诱导的细胞活动有关。
Methods:The expression of TRF1 and TRF2 proteins in 71 human gliomas specimens with different malignant grades were studies using immunohistochemistry methods.
方法：以71例不同级别的人胶质瘤组织为研究材料，用免疫组织化学染色方法检测端粒结合因子TRF1及TRF2蛋白。
Methods: The co immunoprecipitation assay was employed to isolate TRF1 protein complex and the immunoprecipitate was subjected to MALDI TOF mass spectrometry for protein identification.
方法：以TRF1抗体应用免疫共沉淀方法，从细胞蛋白抽提物中分离TRF1蛋白复合物，并作蛋白质肽指纹谱鉴定；
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