This C terminus domain dependent interaction between P53 and TRF1, TRF2 may be related to the cellular activities induced by telomere dynamic changing.
P5 3和TRF1、TRF2这种结构域依赖性的结合可能与端粒动态变化所诱导的细胞活动有关。
Methods:The expression of TRF1 and TRF2 proteins in 71 human gliomas specimens with different malignant grades were studies using immunohistochemistry methods.
方法:以71例不同级别的人胶质瘤组织为研究材料,用免疫组织化学染色方法检测端粒结合因子TRF1及TRF2蛋白。
Methods: The co immunoprecipitation assay was employed to isolate TRF1 protein complex and the immunoprecipitate was subjected to MALDI TOF mass spectrometry for protein identification.
方法:以TRF1抗体应用免疫共沉淀方法,从细胞蛋白抽提物中分离TRF1蛋白复合物,并作蛋白质肽指纹谱鉴定;
Methods: The co immunoprecipitation assay was employed to isolate TRF1 protein complex and the immunoprecipitate was subjected to MALDI TOF mass spectrometry for protein identification.
方法:以TRF1抗体应用免疫共沉淀方法,从细胞蛋白抽提物中分离TRF1蛋白复合物,并作蛋白质肽指纹谱鉴定;
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