Objective To investigate thiopurine methyltransferase(TPMT) activity distribution in Chinese Han and Yao population.

目的研究巯基嘌呤甲基转移酶（TPMT）活性在中国汉族和瑶族人群中的分布。

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TPMT genotype correlates well with in vivo enzyme activity in erythrocytes and is closely associated with risk of toxicity. Genetic mutations are responsible for TPMT deficiency.

TPMT活性具有遗传多态性和种族差异。 TPMT酶活性降低或缺乏与其基因突变密切相关。

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