To study the expression of PLK1 and PCNA in breast carcinoma and its clinical significance.

目的探讨乳腺癌组织中PLK1、增殖细胞核抗原(pcna)的表达及其临床意义。

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Conclusion: Evodiamine could inhibit invasion of human gastric carcinoma cell through down regulating of PLK1 expression.

结论：吴茱萸碱可明显抑制胃癌细胞侵袭力，其机制可能与下调PLK1基因表达有关。

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In addition, while DNA damage has been found to inhibit PLK1 kinase activity, the Thr210Asp mutant is resistant to this inhibition (13).

另外，尽管DNA损伤被发现能够抑制PLK1激酶活性，苏氨酸(210位)被天冬氨酸取代后能够抵制这种抑制作用(13)。

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