Histone acetylation and de-acetylation can change the structure of chromatin, involving in gene expression regulation and nuclear reprogramming.

组蛋白乙酰化和去乙酰化可以改变染色质的结构，参与基因的表达调控和重编程。

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However, nuclear reprogramming, which stands in the way of reconstructed embryo stem cell research, is still a bottleneck in the procedure of nuclear transfer.

但是核重编程仍是核移植技术的瓶颈，制约了重构胚胎干细胞的研究。

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However, unfortunately, poor cloning efficiency and unclear understanding of key mechanisms underlying nuclear reprogramming seriously limit wider USES of animal cloning.

但是，体细胞克隆的效率仍不理想，关键机制还不清楚，严重制约了该技术的推广。

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