Histone acetylation and de-acetylation can change the structure of chromatin, involving in gene expression regulation and nuclear reprogramming.
组蛋白乙酰化和去乙酰化可以改变染色质的结构，参与基因的表达调控和重编程。
However, nuclear reprogramming, which stands in the way of reconstructed embryo stem cell research, is still a bottleneck in the procedure of nuclear transfer.
但是核重编程仍是核移植技术的瓶颈，制约了重构胚胎干细胞的研究。
However, unfortunately, poor cloning efficiency and unclear understanding of key mechanisms underlying nuclear reprogramming seriously limit wider USES of animal cloning.
但是，体细胞克隆的效率仍不理想，关键机制还不清楚，严重制约了该技术的推广。
In general idea, cumulus cell is the best nuclear donor cell for reprogramming.
一般来说，颗粒细胞作为核供体最易被核重编程。
The donor cell and recipient cytoplasm are main factors in the nuclear transfer reprogramming.
供体核和受体胞质是影响核移植重构胚重编程的主要因素。
The donor cell and recipient cytoplasm are main factors in the nuclear transfer reprogramming.
供体核和受体胞质是影响核移植重构胚重编程的主要因素。
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