Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.
细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂，是癌症中较频繁变化的细胞周期调节子。
Objective To discuss the relationship between estradiol and the mitogenic activated protein kinase signal transduction pathway and the expression of the MAPK in the MCF-7 breast cancer cell-line.
目的探讨雌二醇与有丝分裂素激活蛋白激酶（MAPK）信号通路的关系以及MAPK在乳腺癌细胞系中的表达情况。
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