It had never crossed his mind that there might be a problem.

他从来没想到过会有问题。

《柯林斯英汉双解大词典》

The location might be a problem.

位置可能有问题。

youdao

Language might be a problem, I thought.

语言的确是个问题，我想。

youdao

"The problem with resistance means that we might be facing a situation where our currently, mostly susceptible epidemic is replaced in a decade or two by mostly multi-drug resistant disease,".

VOA: standard.2009.12.09

For example, if we talk about photons, of course, we also just mean light, sometimes we refer to this as electromagnetic radiation, and there's several ways that you might be asked this in a problem or that you might be asked to answer.

举例来说，如果我们讨论光子，当然我们也叫做光，有时候我们看作是电磁辐射，而且这里有几种方式,你可能会在题目中被问到,或者被提问回答。

麻省理工公开课 - 化学原理课程节选

Another side effect if you take too much lithium is death, so that's no good to have in sodas either, and it might not have been as big a deal back in the 1920's, but you can imagine with supersizing today, this might be a bigger problem.

另一个副作用是因为摄入锂过量而死，这更说明在汽水里放这种东西是不好的，这在二十世纪二十年代可能没什么大问题，但你可以想象在如今这个什么都超标的时代，这也许会出更大的问题。

麻省理工公开课 - 化学原理课程节选

That means a traditional 4-3 defensive alignment with four fat guys might be a problem.

WSJ: NFL: The Year Everything Changed

So maybe in other countries in France when it's not a problem, here it might be a problem.

NPR: Dispatches from Turkey

If you make too much noise, or fail to pay attention, or let them gather, they might be a problem.

FORBES: 'Dead State' Interview: Why There Are Too Many Zombies, And How To Fund Making More