They appreciated the tricky point that any major change can be stressful.

他们领会到这一难办之处，即任何大的改变都是充满压力的。

youdao

One major change we've made here on the ground floor is to the layout—as you can see from looking around you.

我们在一楼这里做的一个主要改变是改变布局——你看下周围就可以看到。

youdao

The major change is the new XML configuration.

主要的改变就是新的XML配置。

youdao

The next major change in Winslow Homer's life was a decision to work in a new medium.

VOA: special.2010.07.25

So, the banks said, of course we'll do that; that created a major change in mortgage lending.

所以银行说,我们当然愿意这样,这是抵押贷款的一个巨大的变革

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So it was a major change in human evolution where people started raising animals in large groups or started growing plants in large amounts.

这在人来演化史上是个巨大的变革,人类开始大规模饲养动物,或是大量种植农作物

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This would not require any major change of substance, only a small change of style.

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It takes a major change of pace, like a book club, to break down those walls.

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Last summer, Target Stores kicked off a major change in the way drugs were packaged.

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