I do not know self-love, or love of people, is bound to be accompanied by his loneliness and isolation.

不知自爱，也不爱人的人，伴随他的注定是寂寞和孤独。

youdao

As a result he loses everything he has ever sought: his desire for love leads to loneliness and isolation;

他失去了他曾经不断追寻的一切，结果：他对爱的渴望导致了孤独和与世隔绝；

youdao

The fourth part goes to the idea of "Hell is Other People", analyzing the loneliness and isolation of the characters.

第四部分理论源于“他人就是地狱”，分析人物的孤独和隔绝的境况。

youdao

Primarily that would be the weather but we also think loneliness and isolation contributes to that.

BBC: 'Loneliness' increasing in Wales

Other research targeting the social effects of loneliness and isolation have also shown dramatic health risks.

FORBES: Social Interaction Study Highlights Loneliness and Isolation as Heath Risks for Elders

"This required going back into the pain and the loneliness and the isolation and frustration of being a stutterer, " Seidler said.

CNN: Finding words for 'The King's Speech' took decades