I reached the cockpit and directed the extinguisher at the fire without effect.

我进入驾驶舱，把灭火器对准火焰喷射，但没有效果。

《柯林斯英汉双解大词典》

I do not know why the ceiling should be expected to have that effect.

我不明白为什么应该期望天花板产生那种效果。

youdao

To disfigure the mouth—this is how I would interpret it—to disfigure the mouth has a primary effect in rendering one at least temporarily speechless.

把嘴巴丑化——这就是我所理解的——丑化自己的嘴巴使自己暂时不能说话，它是有十分重要影响的。

youdao

"I think this is the big problem of the Abhisit government because his government still believes in trickle-down effect."

VOA: standard.2010.03.24

To disfigure the mouth -- this is how I would interpret it -- to disfigure the mouth has a primary effect in rendering one at least temporarily speechless.

把嘴巴丑化--这就是我所理解的-,丑化自己的嘴巴使自己暂时不能说话,它是有十分重要影响的。

耶鲁公开课 - 弥尔顿课程节选

or that you see the applications of, in day-to-day life and I'd say that's probably... had the biggest effect on me.

或者你能看见，日常生活的应用，让我说这或许是…他对我最大的影响。

我尊敬的教授 - SpeakingMax英语口语达人

To your larger point, I wish the cause-effect relationship of reporting were as simple as you describe it: we report, they react.

FORBES: When Journalism 2.0 Kills

In terms of the effect, I believe that the effect of the -- on the supplies chain that was caused by -- the global supply chain, especially in automobile manufacturing, that was caused by the earthquake and tsunami, that that has certainly diminished.

WHITEHOUSE: Press Briefing

People are quite stupendously lazy if they can't see a direct cause-effect and I think that quite a few of the apathetic - "what difference will my vote make" - bunch would be more likely to exercise their franchise if they didn't have to exercise their legs.

BBC: Matthew Parris